|
T1739 |
WZ811
|
|
CXCR
|
|
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM). |
|
T3047 |
SRT3109
|
|
CXCR
|
|
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions. |
|
T1955 |
SB225002
|
|
CXCR
|
|
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2. |
|
T7681 |
AZD-5069
|
|
CXCR
|
|
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM). |
|
T4163 |
Reparixin
|
DF 1681Y,Repertaxin |
CXCR
|
|
Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM). |
|
T5193 |
Danirixin
|
GSK1325756 |
CXCR
|
|
Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM). |
|
T17208 |
USL311
|
|
CXCR
|
|
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing... |
|
T3992 |
MSX-122
|
MSX 122,MSX122 |
CXCR
|
|
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM). |
|
T10297L |
AMG 487
|
|
CXCR
|
|
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. |
|
T9721 |
ML339
|
|
CXCR
|
|
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4. |
|
T2477 |
UNBS5162
|
UNBS 5162,UNBS-5162 |
CXCR
,
Autophagy
|
|
UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. |
|
T4032 |
MSX-127
|
MSX 127 |
CXCR
|
|
MSX-127 elicites positive response in peptide CXCR4. |
|
T4033 |
MSX-130
|
MSX 130 |
CXCR
|
|
MSX-130 is CXCR4 Antagonist. |
|
TQ0174 |
Mavorixafor
|
AMD-070 |
CXCR
|
|
|
|
T7499 |
TAK-779
|
Takeda 779 |
HIV Protease
,
CXCR
,
CCR
|
|
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). |
|
T8497 |
SX-682
|
|
CXCR
|
|
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer. |
|
T16850 |
SB-265610
|
GSK-CXCR2 |
CXCR
|
|
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and... |
|
T11179 |
Elubrixin
|
SB-656933 |
IL Receptor
,
CXCR
|
|
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat... |
|
T7130 |
Navarixin
|
MK-7123,SCH 527123 |
CXCR
|
|
Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be benef... |
|
T13324 |
VUF11207 fumarate
|
|
CXCR
,
Arrestin
|
|
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1). |
|
T12705 |
Reparixin L-lysine salt
|
Repertaxin L-lysine salt |
CXCR
|
|
Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor. |
|
T7208 |
AMD 3465 hexahydrobromide
|
GENZ-644494 (hexahydrobromide) |
HIV Protease
,
CXCR
|
|
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity. |
|
T6764 |
ATI-2341
|
ATI2341 |
CXCR
|
|
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobil... |
|
T1776 |
Plerixafor
|
JM3100,AMD 3100,AMD-3329 |
Virus Protease
,
HIV Protease
,
CXCR
|
|
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4. |
|
T1776L |
Plerixafor octahydrochloride
|
JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl |
Virus Protease
,
HIV Protease
,
CXCR
|
|
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a... |
|
T76547 |
VMIP-II (1-21)
|
|
|
|
vMIP-II (1-21), a CXCR4 antagonist, exhibits broad-spectrum interaction with both CC and CXC chemokine receptors, specifically binding to CXCR4. It competes for CXCR4 binding of 125I-SDF-1R with an IC 50 value of 190 nM ... |
